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|Molecular Weight::||435.88||Melting Point::||228-229°C|
|Quality Standard:||Enterprise Standard||Storage:||Store Protected From Light And Moisture|
Active Drect Factor Xa Inhibitor Raw Powder Rivaroxaban For Blood clots Treatment
Wuhan Lianshangwang Technology Co.,LTD
Contact person:helena liu
|Quality standard||Enterprise standard|
1) Preventing and treating blood clots in certain patients. It is also used to reduce the risk of stroke and serious blood clots in certain patients with atrial fibrillation.
2) Rivaroxaban is used to treat and prevent deep vein thrombosis (DVT), which can lead to blood clots in the lungs (pulmonary embolism).
3) Rivaroxaban is a direct factor Xa inhibitor. It works by blocking the formation of blood clots.
Rivaroxaban is used to treat deep vein thrombosis (DVT; a blood clot, usually in the leg) and pulmonary embolism (PE; a blood clot in the lung). Rivaroxaban may be continued to prevent DVT and/or PE from happening again after initial treatment is completed. It is also used to help prevent strokes or serious blood clots in people who have atrial fibrillation (a condition in which the heart beats irregularly, increasing the chance of clots forming in the body, and possibly causing strokes) without heart valve disease. Rivaroxaban may reduce the risk of DVT, which can lead to PE in people who are having hip replacement or knee replacement surgery. It is in a class of medications called factor Xa inhibitors. Rivaroxaban works by decreasing the clotting ability of the blood.
Rivaraban is not indicated for prosthetic heart valves or for mitral stenosis.
Rivaroxaban is not indicated as an addon treatment for dual antiplatelet therapy in the secondary prevention of coronary incidents (double and triple therapy). In Europe, however, a 2.mg twicedaily dose was approved by the European Commission after a recommendation by the European Medicines Agency (EMA) for the prevention of atherothrombotic events in adult patients after an acute coronary syndrome (ACS) with elevated cardiac biomarkers co-administered with acetylsalicylic acid (ASA) alone or with ASA plus clopidogrel or ticlopidine.
a) Rivaroxaban comes as a tablet to take by mouth. For the treatment of a DVT and PE, rivaroxaban is usually taken with food twice daily for 21 days, then once daily. When rivaroxaban is taken to prevent DVT and PE, it is usually taken once daily with food. When rivaroxaban is used to prevent a stroke in those with an irregular heartbeat, it is usually taken once daily with the evening meal. When rivaroxaban is taken to prevent DVT and PE after hip or knee replacement surgery it is usually taken with or without food once daily. The first dose should be taken at least 6 to 10 hours after surgery. Rivaroxaban is usually taken for 35 days after a hip replacement surgery and for 12 days after knee replacement surgery. Take rivaroxaban at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take rivaroxaban exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
b) If you are unable to swallow the tablets, you can crush them and mix with applesauce. Swallow the mixture right after you prepare it. Rivaroxaban can also be given in certain types of feeding tubes. Ask your doctor if you should take this medication in your feeding tube. Follow your doctor's directions carefully.
c) Continue to take rivaroxaban even if you feel well. Do not stop taking rivaroxaban without talking to your doctor. If you stop taking rivaroxaban, your risk of a blood clot may increase.
Rivaroxaban Test Report:
|Appearance||White or off-white powder||White powder|
|A. IR(KBr)||The sample spectrum corresponds to that of the working standard||Confirm|
|B. HPLC||The retention time of the major peak in the chromatogram of the sample corresponds to that exhibited by the working standard||Confirm|
|Single impurity||Not more than 0.1%||0.08%|
|Total impurities||Not more than 1.0%||0.5%|
|E.e %||More than 98.5%||99%|
|Assay (by HPLC)||Not less than 98.0% and not more than 102.0% w/w||99.1%|
|Conclusion||Comply with In-house standard.|
|Storage||Store protected from light and moisture|
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