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Royal Jelly Acid 10 - Hydroxy - 2 - Decenoic Acid / 10 - HDA For Antitumor Activity , 14113-05-4

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Royal Jelly Acid 10 - Hydroxy - 2 - Decenoic Acid / 10 - HDA For Antitumor Activity , 14113-05-4

China Royal Jelly Acid 10 - Hydroxy - 2 - Decenoic Acid / 10 - HDA For Antitumor Activity , 14113-05-4 supplier
Royal Jelly Acid 10 - Hydroxy - 2 - Decenoic Acid / 10 - HDA For Antitumor Activity , 14113-05-4 supplier Royal Jelly Acid 10 - Hydroxy - 2 - Decenoic Acid / 10 - HDA For Antitumor Activity , 14113-05-4 supplier Royal Jelly Acid 10 - Hydroxy - 2 - Decenoic Acid / 10 - HDA For Antitumor Activity , 14113-05-4 supplier Royal Jelly Acid 10 - Hydroxy - 2 - Decenoic Acid / 10 - HDA For Antitumor Activity , 14113-05-4 supplier Royal Jelly Acid 10 - Hydroxy - 2 - Decenoic Acid / 10 - HDA For Antitumor Activity , 14113-05-4 supplier

Large Image :  Royal Jelly Acid 10 - Hydroxy - 2 - Decenoic Acid / 10 - HDA For Antitumor Activity , 14113-05-4

Product Details:

Place of Origin: China
Brand Name: SBJ
Certification: ISO9001, SGS, USP, BP
Model Number: 14113-05-4

Payment & Shipping Terms:

Minimum Order Quantity: 10g
Price: Negotiated (Best offer will be provided based on your quantity)
Packaging Details: Professional discreet package, Foil bag or as your demand.
Delivery Time: Within 24 hours after payment
Payment Terms: Western Union, MoneyGram, Bank transfer, Bitcoin
Supply Ability: Plenty In Stock (New Batch)
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Detailed Product Description
Full Name: 10 - Hydroxy - 2 - Decenoic Acid Assay: ≥ 98%
M F: C10H18O3 M W: 186.25
Accurate Mass: 186.125595 Period Of Validity: 2 Years
Email: Coco@yuanchengtech.com Whatsapp: +86 18872220806

 

Royal Jelly Acid 10 - Hydroxy - 2 - Decenoic Acid / 10 - HDA For Antitumor Activity 14113-05-4

 

 

Wuhan Lianshangwang Technology Co.,LTD

Contact person:helena liu

coco@yuanchengtech.com

whatsapp:+86 18872220806

 

 

10 - HDA Details:

 

Full name 10 - Hydroxy - 2 - Decenoic Acid
CAS No. 14113-05-4
Assay ≥ 98%
M F C10H18O3
M W 186.25
Percentage Composition C 64.49%; H 9.74%; O 25.77%
Accurate Mass

186.125595

Biological Source Constit. of royal jelly
Solubility Sol. MeOH, Et2O, bases; poorly sol. H2O
Storage conditions  4 °C refrigerated, sealed, avoid light

 

 

 

 

10 - HDA Description:

 

10 - Hydroxy - 2 - Decenoic Acid is an unsaturated fatty acid found in royal jelly produced from the hypopharyngeal and mandibular gland secretions of honeybees.

10 - Hydroxy - 2 - Decenoic Acid has longevity-promoting effects in C. elegans at a concentration of 25 μM.2 It down-regulates matrix metalloproteinasesin rheumatoid arthritis synovial fibroblasts at a concentration of 1.25 nM and inhibits VEGF-induced angiogenesis in HUVECs at 500 μM.3,4

10 - Hydroxy - 2 - Decenoic Acid also facilitates differentiation of neurons from neural stem/progenitor cells and promotes collagen production by skin fibroblasts at concentrations of 100 μM and 1.5 mM, respectively.

The finding indicates 10 - Hydroxy - 2 - Decenoic Acid extends lifespan through dietary restriction signaling. We further found that 10 - Hydroxy - 2 - Decenoic Acid did not extend the lifespan of the long-lived mutants in daf-15, which encodes Raptor, a target of rapamycin (TOR) components, indicating that 10 - Hydroxy - 2 - Decenoic Acid shared some longevity control mechanisms with TOR signaling. Additionally, 10 - Hydroxy - 2 - Decenoic Acid was found to confer tolerance against thermal and oxidative stress. 10-HDA increases longevity not through ILS but through dietary restriction and TOR signaling in C

 

Vascular endothelial growth factor is reported to be a potent pro-angiogenic factor that plays a pivotal role in both physiological and pathological angiogenesis. Royal jelly is a honeybee product containing various proteins, sugars, lipids, vitamins and free amino acids. 10-Hydroxy-2-decenoic acid, a major fatty acid component of RJ, is known to have various pharmacological effects; its antitumor activity being especially noteworthy. However, the mechanism underlying this effect is unclear. We examined the effect of 10HDA on VEGF-induced proliferation, migration and tube formation in human umbilical vein endothelial cells . Our findings showed that, 10HDA at 20 µM or more significantly inhibited such proliferation, migration and tube formation. Similarly, 10 µM GM6001, a matrix metalloprotease inhibitor, prevented VEGF-induced migration and tube formation. These findings indicate that 10HDA exerts an inhibitory effect on VEGF-induced angiogenesis, partly by inhibiting both cell proliferation and migration. Further experiments will be needed to clarify the detailed mechanism.

 

 

10 - HDA Function:

 

>> Lower blood fat and prevent arteriosclerosis;
>> Lower blood sugar and enhance memory;
>> Improve intelligence;
>> Promotion of hematopoietic function;
>> Regulation of the endocrine and metabolic;
>> Anti-aging, anti-radiation and promot tissue regeneration;
>> Improve immunity, anti-influenza and anti-hepatitis;
>> Beautifying&moisturizing skin;

>> Prevention of cancer and other physiological functions.

 

 

10 - HDA Test Report:

 

ITEM SPECIFICATION UNIT RESULT METHOD

Acid

33-53

ml/100g

37

GB 9697-2008

Ash

0.5-0.9

%

0.6

GB 9697-2008

Foreign Matter

0.01max

%

<0.01

GB 9697-2008

Pesticide Residues

Complies with EU Regulation of the organic products

Mg/kg

Not detected

LC-MS/MS

Heavy Metals

Lead

0.01-0.05

mg/kg

0.01

GB/T 5009

Arsenic

<0.01

mg/kg

<0.01

GB/T 5009

Cadmium

<0.01

mg/kg

<0.01

GB/T 5009

Mercury

<0.01

mg/kg

<0.01

GB/T 5009

Microbiology

Total Plate Count

<1000

cfu/g

10

GB 9697-2008

Coliform

<30

MPN/100g

<30

GB 9697-2008

Yeast / Mould

<50

cfu/g

<10

GB 9697-2008

E.Coli

Negative

/

ND

GB 9697-2008

Staphylococcus Aureus

Negative

/

ND

GB 9697-2008

Salmonella

Negative

/

ND

GB 9697-2008

Antibiotics

Chloramphenicol

<0.1

PPb

<0.1

LC-MS/MS

Nitrofurans&Metabolites

<1.0

PPb

<0.5

LC-MS/MS

Sulphonamides

<10

PPb

<10

LC-MS/MS

Fluoroquinolones

<10

PPb

<2.5

LC-MS/MS

Tetracyclines

<10

PPb

<10

LC-MS/MS

Nitroimidazoles

<0.5

PPb

<0.5

LC-MS/MS

Streptomycin

<10

PPb

<10

LC-MS/MS

Macrolides

<10

PPb

<10

LC-MS/MS

Amitraz Coumafos

<10

PPb

<10

LC-MS/MS

 

 

 

 

 

Competitive advantages

1) As a leading manufacture, Our products have been exported to Norway, Poland, Finland, Spain, UK, France, Germany, Russia, USA, Brazil, Mexico, Australia, Japan, Korea, Thailand, Indonesia, Uruguay and many other countries.

2) We have Flexible and Untraceable payment terms.
5) We offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best after-sale service is our philosophy.

 


Delivery and Packing

>> 100% Custom Pass Guarantee
>> Professional and Well trained Packing Team
>> Prompt delivery, In 24 hours delivery after payment

>> Packing pictures and tacking code provided in 2 days after Delivery.
>> 24/7 after sale service.

 

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Royal Jelly Acid 10 - Hydroxy - 2 - Decenoic Acid / 10 - HDA For Antitumor Activity , 14113-05-4

 

 

 

Thank you for interested in our product.

We are the professional manufacturer over 15 years, good reputation in the globe trade.

Most of our product are USP standard, and available anytime; good quality and high purity you should enjoy.

It's important for you to choose a business partner who can offer a competitive price

 

CONTACT US

 

coco@yuanchengtech.com

whatsapp:+86 18872220806

 

 

 

 

Contact Details
Wuhan Lianshangwang Technology Co.,LTD

Contact Person: Cindy Steroids

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