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|Molecular Weight::||357.7802||Grade Standard:||Medicine Grade|
Medicine Grade Raw Powder Indometacin For Antiinflammatory Agent
Wuhan Lianshangwang Technology Co.,LTD
Contact person:helena liu
|Type:||Antibiotic and Antimicrobial Agents|
|Grade Standard:||Medicine Grade|
|Boiling point:||499.4°C at 760 mmHg|
|Vapour Pressur:||8.61E-11mmHg at 25°C|
|Hazard Symbols:||T+:Very toxic;|
|Application:||An inhibitor of Cox-1 and activator of PPAR|
|Storage:||Store at room temperature|
Indomethacin is an antiinflammatory agent, inhibits Cox-1 and Cox-2 (cyclooxygenases) with selectivity for Cox-1 (IC50 of 230 nM) over Cox-2 (IC50 of 630 nM).
Additionally, indomethacin displays adipogenic actions via binding and activation of PPARγ (peroxisome proliferator-activated receptor γ), a ligand-activated transcription factor known to play an important role in adipogenesis. Other studies show indomethacin to stabilize cholesterol-dependent nanoclusters and enhance phase separation in biological membranes, which could consequentially effect plasma membrane assembled cell signaling cascades. Indomethacin is an activator of PPAR α.
Indometacin has obvious effect on anti-inflammation and antipyretic, can be easily absorbed and excreted. It can be fully absorbed after taken orally in the gastrointestinal tract, and in 1-4 hours the plasma concentration will reach a peak; it will be excreted by liver metabolism, with the urine.
Analgesic effects on inflammatory pain there, and its mechanism of inhibiting prostaglandin synthesis. Salicylic acid is mainly used on the efficacy of drugs difficult to tolerate, or not significant rheumatoid arthritis, ankylosing spondylitis, osteoarthritis and so on. Can also be used for acute gout and cancer, fever, or other difficult to control fever.
Indometacin Test Report:
|Appearance||White or yellow crystalline powder||Conforms|
|Absorption at 318nm||170-190||185.6|
|Loss on drying||≤0.5%||0.07%|
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