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|Molecular Formula:||C15H16O3||Molecular Weight (g/mol):||244.28574|
|Appearance:||Greenish Yellow Or White Fine Powder||Chemical Family:||Coumarins|
|General Source:||Cnidium Monnieri||Function:||Cnidium Seed Has Been Very Commonly Used In Formulations Designed To Warm The Kidneys And Strengthen Yang Energy|
Natural Coumarin Osthol / Osthole For Anti-inflammatory CAS 484-12-8
Wuhan Lianshangwang Technology Co.,LTD
Contact person:helena liu
|Molecular Weight (g/mol)||244.28574|
|Appearance||Greenish Yellow or white fine powder|
|General Source||Cnidium monnieri|
|Function||Cnidium seed has been very commonly used in formulations designed to warm the Kidneys and strengthen Yang energy|
It is primarily used for the purpose of overcoming sexual malaise and strengthening sexual potency. The classics repeatedly mention it as an aphrodisiac.
Osthole Storage: Stored in a cool and dry well-closed container, keep away from moisture and strong light / heat.
Osthole ≥10%, 35%, 50%, 70%, 80%, 90%, 95%, 98% HPLC detection methods (HPLC)
Osthole traits conventional 35%, 50% and other low content of yellow-green powder, high levels of white needle crystal powder. Yellow-green powder or white crystalline powder, the air is fragrant, spicy and cool, Ma tongue sense.
Osthole Melting point: mp.83 ºC ~ 84 ºC, bp.145 ºC ~ 150 ºC, soluble in methanol, ethanol, chloroform, acetone, ethyl acetate, and boiling petroleum ether, insoluble in water and petroleum ether .
Packing: 1kg / bag; 25kg / drum; or packaged according to customer demand.
Osthol save in a cool, dry, dark, avoid high temperature.
Osthole, is a natural coumarin which was first isolated from several medicinal plants, including C. monnieri and A. pubescens.
Osthole is reported to induce a nonspecific elevation of cAMP and cGMP levels through its ability to inhibit phosphodiesterases, which leads to a modulation of calcium channel signaling and vasorelaxant effects. Osthole exhibits immunomodulatory, antioxidative, and anti-inflammatory properties, by regulating the expression of TNF-α, NF-κB, TGF-β, cyclooxygenases, leukotrienes, nitric oxide, ERK, and JNK.
Osthole also demonstrates antifibrotic effects in both hepatic and myocardial tissues and has been suggested to be a natural activator of defective delta F508-cystic fibrosis transmembrane conductance regulator chloride channel gating
Osthole, also called osthol, 7-methoxy-8-(3-methyl-2-butenyl)-2H-1-benzopyran-2-one, is a natural coumarin first derived from Cnidium plant. High content of osthole is found in the mature fruit of Cnidium monnieri (Fructus Cnidii), which is commonly applied in clinical practice of Traditional Chinese Medicine (TCM), while it is also widely found in other medicinal plants including Angelica, Archangelica, Citrus, Clausena.
Fructus Cnidii strengthens immune system and improves male function, relieving rheumatic pain and eliminating dampness; most of these medicinal properties are considered to attribute to one of its major bioactive components, osthole. Modern researches have suggested that osthole exhibits antioxidant, anticancer, anti-inflammatory, and immunomodulatory properties.
With multiple bioactivities of osthole reported, developing osthole and derivatives as potential multitarget drug should be encouraged. Thence it is meaningful to summarize the pharmacological and biological researches on this coumarin, to review the mechanisms behind the effects and get a comprehensive picture of its miscellaneous functions.
1) Benefit people suffered from some chronic conditions.
Because of its unique structure, the location of a butenyl group at position-8, researchers
from Nippon Chemiphar Co., Ltd, believe s osthole is a good candidate l for liver cancer
(hepatocellular carcinomas). Osthole exhibited a significant induction of differentiation in two human osteoblast-like cell lines-MG-63 and hFOB. Researchers from Chia-Nan University of Pharmacy and Science,Taiwan, claimed that osthole may benefit people suffered from osteoporosis. In a study of
ovariectomized rats, osthole was as effective as 17beta-estradiol to suppress bone loss
due to ovariectomy but the researchers were not sure how osthole suppress bone loss.
2) Anti-inflammatory Action
Researchers from Gannan Medical College, China, found that osthole suppressed inflammatory responses on nitric oxide levels in a dose-dependent manner in a study of rats.The mechanism is related to inhibition of calcium entry and elevating cGMP levels way.
3) Benefit people at risk of hypertension
Researchers noted that the mechanism might work via interfering the calcium influx and cyclic nucleotide
phosphodiesterases. Osthole causes hypotension in vivo or lowers the blood pressure of animals, and inhibits platelet aggregation and smooth muscle contraction in vitro.
|Purity Osthole||10-98% by HPLC|
|Powder size||100% pass 80 mesh|
|Loss on Drying||≤5.0%|
|Total Plate Count||1000cfu/g|
|Yeast & Mold||100cfu/g|
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