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|Alias:||Lentaron, 4-hydroxyandrost-4-ene-3,17-dione||Appearance:||Off-white Crystalline Powder|
|Usage:||An Antitumor Drug. An Aromatase Inhibitor||Dosage:||250mg, 1 Time Every Two Weeks, As The Arm Deep Intramuscular Injection.|
Selective Aromatase Inhibitor Steroid Lentaron / Formestane For Anti- estrogen
Wuhan Lianshangwang Technology Co.,LTD
Contact person:helena liu
Formestane, also known as Lentaron, 4-hydroxyandrost-4-ene-3,17-dione, is a type I, steroidal, selective aromatase inhibitor. It is used in the treatment of estrogen receptor-positive breast cancer in postmenopausal women. The drug is not active orally, and is instead available only as an intramuscular depot injection. Because of this, it is no longer popular as many orally active aromatase inhibitors have been identified and introduced. Formestane is an analogue of androstenedione.
Formestane is often used to suppress the production of estrogens from anabolic steroids or prohormones. It also acts as a prohormone to 4-hydroxytestosterone, an active steroid which displays weak androgenic activity in addition to acting as a weak aromatase inhibitor.
|Appearance||off-white crystalline powder|
|Usage||An antitumor drug. An aromatase inhibitor|
|Dosage||250mg, 1 time every two weeks, as the arm deep intramuscular injection.|
|Melting Point||199-202 °C|
|Boiling Point||475.4 °C at 760 mmHg|
|Flash Point||255.4 °C|
|Packing||Foil bag or as requirments|
Formestane is an aromatase inhibitor which significantly reduces plasma levels of estrogen and has shown antitumour activity in postmenopausal women with breast cancer. Objective response rates in heavily pretreated patients with advanced breast cancer generally range between 20 and 30% during treatment with intramuscular formestone 250 or 500mg once every 2 weeks, and a further 20 to 30% of patients experience disease stabilisation. The median duration of response is between 8 and 14 months. Highest response rates are observed in soft tissue metastases, in patients with estrogen-responsive tumours and in those showing a response to previous endocrine therapy. Furthermore, there is some evidence to suggest that higher response rates are achieved with formestane 500 versus 250mg once every 2 weeks. In comparative studies, the clinical efficacy of intramuscular formestane 250mg did not differ significantly from that of oral megestrol when administered as second-line endocrine therapy to patients with advanced disease in whom previous tamoxifen therapy had failed. In addition, formestane produced a response rate, duration of response and overall survival rate that was not significantly different from that of oral tamoxifen when administered as first-line endocrine therapy to patients with advanced disease, but tamoxifen was superior in some measures. Further investigation of these 2 agents, including the higher dosage of formestane 500mg, is necessary to confirm their relative efficacies.
Formestane Test Report:
|Appearance||White or Almost White Crystalline Powder||Conforms|
|Loss On Drying||≤0.50%||0.32%|
|Conclusion||The specification conform with Enterprise standard|
|QA manager||Dexin Yang||Analyst||Jiaojiao Chen|
Formestane was dosed at 100-200mgs per application. Users would apply it onto clean, dry skin and rub in thoroughly; usually on the thighs or upper arms. It took 1 to 5 minutes to dry.
1) Formestane was originally used as an injectable for breast cancer patients, but due to its possible androgenic effects it has largely been replaced by non-steroidial AIs in the medical community. Most of its use is now is limited to the bodybuilding community since it is available as a legal dietary supplement for reducing estrogen and increasing testosterone production.
2) Although formestane can effectively reduce estrogen through oral consumption, its low oral bioavailability has lead to the development of several transdermal based products (which appear to offer higher efficacy at a lower dose).
3) Relative to 6-oxo and ATD, Formestane is a more potent aromatase inhibitor, which appears to effectively reduce natural estrogen levels by as much as 50% within several days (while higher doses may further suppress estrogen). Because of formestanes potent ability at reducing estrogen it will tend to reduce HDL levels, while increasing LDL levels, thus harming the cholesterol profile. For this reason, it is recommended to limit cycles of formestane to 8 weeks max.
4) Because formestane also has a strong affinity for the 5a-reductase enzyme it will reduce DHT levels in the body by effectively competing with testosterone for the 5a-reductase.
Formestane converts to the active androgen 4-hydroxytestosterone which has about half the anabolic potency, and about 25% of the androgenic potency as testosterone. This would suggest that fairly high doses of formestane (800-1000mg/day) could lead to some level of anabolic enhancement (although the amount required for this would surely lead to undesirably low estrogen levels).
Anti- estrogen Steroids for reference:
Tamoxifen Citrate (Nolvadex)
Parcel Safety Shipping and Package
We according to different countries, choose the safest way to ensure products to be delivered in 3 to 7 working days, and packaging based on latest customs clearance, constantly updated to ensure products clearance rate.
Our goods packing will not contain any hormone information and can be sent out from different areas of china. At present,the goods customs clearance rate we send to United states and Europe is 99%, As for Canada, Brazil of quite high buckle close rate area, we also have a new way to get through the customs. We also have completely re-send policy to some areas
At present,the goods customs clearance rate we send to United states and Europe is 99%, As for Canada, Brazil of quite high buckle close rate area, we also have a new way to get through the customs. We also have completely re-send policy to some areas.
If Seized by custom, we reship for free. Pls donot worry.
SBJ Powder for reference:
|Testosterone Acetate||Trenbolone Acetate|
|Testosterone Cypionate||Trenbolone Enanthate|
|Testosterone Decanoate||Boldenone Acetate|
|Testosterone Enanthate||Boldenone undecylenate|
|Testosterone Isocaproate||Boldenone Cypionate|
|Testosterone Phenylpropionate||Boldenone Propionate|
|Testosterone Propionate||Nandrolone Decanoate|
|Testosterone Undecanoate||Nandrolone phenylpropionate|
|Testosterone Sustanon 250||Nandrolone cypionate|
|Clostebol Acetate||Nandrolone propionate|
|Methenolone Enanthate||Drostanolone Propionate|
|Methenolone Acetate||Drostanolone Enanthate|
|Toremifene citrate||Tamoxifen Citrate|
|Selank 5mg/vial||DSIP 2mg/vial|
|MGF 2mg/vial||PEG MGF 2mg/vial|
|CJC-1295 with DAC 2mg/vial||CJC-1295 without DAC 2mg/vial|
|PT-141 10mg/vial||MT-1 10mg/vial|
|MT-2 10mg/vial||GHRP-2 5mg/vial|
|GHRP-6 5mg/vial||GHRP-6 10mg/vial|
|Ipamorelin 2mg/vial||Hexarelin 2mg/vial|
|Sermorelin 2mg/vial||Oxytocin 2mg/vial|
|TB500 2mg/vial||Pentadecapeptide BPC 157 2mg/vial|
|Triptorelin 2mg/vial||Tesamorelin 2mg/vial|
|Gonadorelin 2mg/vial||Gonadorelin 10mg/vial|
For more details, freely contact me
Contact person:helena liu