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|Appearance:||White Or Almost White Crystallime Powder||Assay:||≥ 99 %|
|Melting Point:||72~76 ℃||Heavy Metals:||≤ 20 Ppm|
Weight Loss Drug White Powder Cetilistat for Treatment of Obesity CAS 282526-98-1
1) Cetilistat Details
White or almost white crystallime powder
A novel pancreatic lipase inhibitor for the treatment of obesity in both diabetic and non-diabetic patients.
1kg/ Foil bag
2) Uses for Cetilistat
Cetislim (Cetilistat) is a weight loss drug used in combination with a low calorie diet. It works by blocking a substantial amount of fat from being digested and absorbed into the body. This medicine is classified as a lipase inhibitor and it works directly on the digestive system where it blocks the action of a lipolytic enzyme called lipase. These lipases are what the body uses to digest the fat.
However, when this medicine is administered alongside a meal, it binds to the lipases, thereby inhibiting them from breaking down the fat. Fats which are not hydrolyzed are instead excreted in the feces, resulting in increased fecal fat excretion and reduced fat absorption. When used together with a reduced calorie diet, it can help improve weight loss and make it easier for overweight patients to get back in shape, thereby boosting the chances of successful weight loss.
3) Cetilistat Specification
|Test Items||Specification||Test Results|
|Appearance||White or almost white crystallime powder||White powder|
|Loss on drying||≤1.0 %||0.86%|
|Melting Point||72~76 ℃||73.5-75.2℃|
|Residue on ignition||≤ 0.5%||0.33%|
|Related Substances||≤ 1.0 %||0.44%|
|Heavy Metals (ppm)||≤ 20 ppm||Conformed|
|Assay||≥ 99 %||99.65%|
4) How is Cetislim Used?
Cetislim is usually taken orally as directed by a doctor. The medication can be taken with, during or even up to 1 hour after each main meal. If you skip a meal, do not take the medication. Swallow the capsules whole with a glass of water. Contact a doctor for the correct dosage and length of treatment as it will depend on the patients condition and their response to the therapy.
5) Therapeutic Approaches to Treatment of Obesity
The growing prevalence of obesity has stimulated the search for drugs to treat this condition. Various therapeutic strategies have been explored, including:
Serotonin and noradrenaline reuptake inhibitors (anorectic agents)
b 3-adrenoreceptor agonists
Endocannabinoid receptor antagonists
Cetilistat is a lipase inhibitor, with a similar mode of action to Roche's anti-obesity medication orlistat (Xenical®) which received regulatory approval in 1997. These drugs act in the gastrointestinal tract to inhibit lipases, enzymes involved in the breakdown of dietary fats. By inhibiting the breakdown and subsequent absorption of fats from the gut, lipase inhibitors reduce fat intake and calories, thus aiding weight loss.
6) Evidence of Efficacy and Tolerability in Obese Adults
The clinical efficacy and safety of cetilistat has been demonstrated in a series of Phase II trials. A Phase IIb clinical trial in 612 clinically obese diabetic patients showed that over a 12-week treatment period, cetilistat 80mg and 120mg promoted significant weight loss compared with placebo (3.85kg and 4.32kg versus 2.86kg respectively), thus meeting the trial's primary endpoint.
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