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|EINECS:||219-034-4||Appearance:||White Crystalline Powder|
Pharmaceutical Raw Materials Methoxygonadiene / Max-LMG for Decreasing Estrogen-like Effects
Wuhan Lianshangwang Technology Co.,LTD
Contact person:helena liu
|Synonyms||Methoxygonadiene;13-Ethyl-3-Methoxy-Gona-2,5(10)-Diene-17-One;Max-LMG; M-LMG;3-Methoxy-18-methylestra-2,5(10)-dien-17-one;18-Methylestra-2,5(10)-dien-3-ol-17-one-3-methy ether|
|Character||White crystalline powder|
|Melting point||150-160 ℃|
|Usage||18-levonorgestrel, Gestrinone intermediates.Max LMG is a progestin derived steroid and not a 17-alpha alkylated steroid. Max LMG is structurally related to RU-486 and acts as an antiprogesterone, decreasing estrogen-like effects.|
2) Methoxydienone Structure and Function
Methoxydienone belongs to a class of steroids called gonanes. The most basic gonane is a steroid
devoid of the C-10 and C-13 methyl groups and is generally referred to as the ‘steroid nucleus’.
Herchel Smith and Richard Edgren originally described hormones such as methoxygonadiene and norbolethone as “13-substituted bisnortestosterones”, though they soon switched to the gonane nomenclature system to avoid confusion.
Since by the strictest definition all steroids can be considered gonanes, Edgren has expressed a preference for the term “carbon 18-homologated 19-nortestosterones”, or alternatively “levonorgestrel family of progestins” for 18-methyl hormones such as methoxygonadiene.
In fact it’s almost entirely unrelated, structurally, to the “abortion pill” RU-486 (Mifepristone), as can be seen by even a cursory glance at the molecular structures.
It’s possible that the confusion may have arisen because Wyeth’s oral contraceptive Nordette (which contained ethinyl estradiol and levonorgestrel) was marked “Wyeth” on one side, and “486” on the
other. Since levonorgestrel can be made from methoxygonadiene, a comparison with that compound would have been much more appropriate.
Methoxygonadiene is not 5-alpha-reduced, or even remotely related to DHT. It has a double bond from C5-C10, which it’s believed may isomerise in vivo to the more thermodynamically stable C4-C5 position.
Contrary to the assertion above, this compound is noted by users for a high degree of water retention – and is certain to aromatise. Ironically, both of the compounds sold by ALRI under the name “LMG”
(Lean Mass Generator) were renowned for doing the opposite: Ergomax LMG (desoxymethyltestosterone; “Pheraplex”) was also usually characterized as a “wet bulker” that caused significant water retention.
3) Methoxydienone Specification
|Boiling Point||448 ℃ at 760 mmHg|
|Flash Point||188.8 ℃|
|Storage||Cool,dry place and keep from light|
4) Anabolic and Androgenic Activity
Methoxygonadiene is believed to act as a ‘prodrug’, deriving pharmacological activity by being metabolised to an active compound. Methoxygonadiene is unlikely to have any ‘intrinsic’ anabolicactivity due to the lack of a 17b-hydroxyl function.
The diagram above illustrates the commonly suggested metabolic route. According to the scheme proposed, after ingestion methoxydienone’s enol ether group (methoxy) will undergo hydrolysis tothe 3-ketone and the remaining 5(10) double bond should isomerize readily under acidic conditionsin the body to produce a 4-en-3-one conjugation. It will then further convert to the biologically active17b-hydroxyl steroid, 18-methyl-19-nortestosterone.18-methyl-19-nortestosterone is a potent anabolic by injection, holding an A:A ratio of approximately 54:27 (LA:VP vs. testosterone propionate). and 90:625 (LA:VP vs. 19-nortestosterone). No data is available on the oral activity of either methoxygonadiene or 18-methyl-19-nortestosterone.
5) Presentation of the Max LMG Prohormone
Max LMG prohormones (also called Methoxygonadiene) were cloned many times over the past years. Max LMG became really popular because this is non a methylated prohormone (not banned) that delivers middle range results.
The active compound of Max LMG prohormones is 13-ethyl-3-methoxy-gona-2,5(10)-diene-17-one. Max LMG prohormones are progestin based compound and they give some sort of water retention.
As of today, multiples clones of Methoxygonadiene are available and it’s a good prohormone to run in solo or in a prohormone stack.
6) Recommend Products
|Steroids APIs||CAS NO|
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Contact person:helena liu
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