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|Product Name:||Pregabalin||Appearance:||Off-White Solid Powder|
|Application:||Anticonvulsant Neurochemicals Pharmaceutical||Email:||Zai@chembj.com|
Pregabalin Lyrica Pharmaceutical Raw Materials Antiepileptic Treatment Drugs Pregabalin
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Pregabalin Basic info :
Synonym: Pregablin;3-(Aminomethyl)-5-methyl-hexanoic acid
Appearance: White Crystal Powder
Payment: T/T, Western Union and Money Gram
Delivery: Within 24hours After Your Payment
Express: EMS, DHL, FedEx, etc(door-to-door)
Usage: New antiepileptic drugs. Used in the treatment of peripheral neuropathy, or partial seizures adjuvant treatment.
Pregabalin works by reducing the abnormal electrical activity in the brain. It is taken alongside other medicines for epilepsy. Pregabalin can also be helpful in treating the symptoms of generalised anxiety disorder (GAD), particularly if other medicines which are more often prescribed for people with this condition are not suitable. GAD is a long-term condition where anxiety is a major symptom.
Pregabalin, also known as β-isobutyl-γ-Aminobutyric acid (β-isobutyl-GABA) and sold under the trade name Lyrica among others, is a medication used to in the treatment of epilepsy, neuropathic pain, fibromyalgia and generalized anxiety disorder. Its use for epilepsy is as an add-on therapy for partial seizures with or without secondary generalization in adults.
Pregabalin is a structural analogue of the neurotransmitter GABA, consequently it belongs to the γ-Aminobutyric acid analogue class of antiepileptic drugs. Its a ion channel modulator that has analgesic, anticonvulsant, sedative, and anxiolytic properties. Pregabalin is a potent gabapentinoid and close analogue of GABOB (β-hydroxy-GABA), baclofen (β-(4-chlorophenyl)-GABA), and phenibut (β-phenyl-GABA).
Pregabalin belongs to a group of medicines known as anti-epileptic medicines, although it is prescribed for the treatment of several different conditions. You may have been prescribed it for the treatment of partial seizures, which is a type of epilepsy. A seizure is a short episode of symptoms which is caused by a burst of abnormal electrical activity in the brain. With a partial seizure, the burst of electrical activity stays in one part of the brain. Therefore, you tend to have localised or 'focal' symptoms. Pregabalin is also prescribed to treat certain types of long-lasting pain caused by damage to nerves. This type of pain, called neuropathic pain, can be caused by a number of different conditions, including diabetes (where it is called diabetic neuropathy) and shingles(where it is called postherpetic neuralgia).
Pregabalin is useful when added to other treatments, when those other treatments are not controling partial epilepsy. Its use alone is less effective than some other seizure medications. It is unclear how it compares to gabapentin for this use.
The European Federation of Neurological Societies recommends pregabalin as a first line agent for the treatment of pain associated with diabetic neuropathy, post-herpetic neuralgia, and central neuropathic pain. A minority obtain substantial benefit, and a larger number obtain moderate benefit. Other first line agents, including gabapentinand tricyclic antidepressants, are given equal weight as first line agents, and unlike pregabalin, are available as less expensive generics.
Pregabalin is not recommended for certain other types of neuropathic pain such as pain that of trigeminal neuralgia or HIV infection and its use in cancer-associated neuropathic pain is controversial.There is no evidence for its use in the prevention of migraines and gabapentin has been found not to be useful. It has been examined for the prevention of post-surgical chronic pain, but its utility for this purpose is controversial.
Pregabalin is generally not regarded as efficacious in the treatment of acute pain. In clinical trials examining the utility of pregabalin for the treatment of acute post-surgical pain, no effect on overall pain levels was observed, but people did required less morphine and had fewer opioid-related side effects.
The World Federation of Biological Psychiatry recommends pregabalin as one of several first line agents for the treatment of generalized anxiety disorder, but recommends other agents such asSSRIs as first line treatment for obsessive-compulsive disorder and post-traumatic stress disorder.It appears to have anxiolytic effects similar to benzodiazepines with less risk ofdependence.
Therapeutic effects of pregabalin appear after 1 week of use and is similar in effectiveness to venlafaxine, but pregabalin has demonstrated superiority by producing more consistent therapeutic effects for psychic and somatic anxiety symptoms.Long-term trials have shown continued effectiveness without the development of tolerance, and, in addition, unlike benzodiazepines, it has a beneficial effect on sleep and sleep architecture, characterized by the enhancement of slow-wave sleep. and produces less severe cognitive and psychomotor impairment; it also has a low potential for abuse and dependence and may be preferred over the benzodiazepines for these reasons.
|Appearance||A white to off white powder||White powder|
|Identification||A. Meets the requirement||Complies|
|B. IR: similar to Reference Substance||Complies|
|Loss on drying||≤0.5%||0.21%|
|Related Substances||Any single impurity ≤0.1%
Total impurity ≤0.8%
|Purity By HPLC R-isomer||≤0.15%||0.10|
|Residue on ignition||≤0.1%||0.05%|
|Residual solvents||Isopropyl alcohol ≤5000ppm
Ethyl Acetate ≤5000ppm
|Conclusion||Analyse according to Factory Standard , Conform
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