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|Appearance:||White Or Straw Yellow Crystalline Powder||Standard:||Enterprise Standard|
Pharmaceutical Intermediates Dehydroepiandrosterone Acetate For Nutritional Supplements
1) Dehydroepiandrosterone Acetate Details
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Name: Dehydroepiandrosterone Acetate
Synonyms: dehydroisoandrosterone 3-acetate; Epiandrosterone Acetate; Prasterone acetate;
Molecular Weight: 330.47
Character : White or straw yellow crystalline powder
Quality Standard: Enterprise Standard
Usage: Pharmaceutical intermediates, For the synthesis of steroid hormone drugs. Preparation Products Epiandrosterone acetate-->Methandriol
Packing: foil bag or tin.
2) Dehydroepiandrosterone Acetate Usage
DHEA acetate treatment affected body weight, body composition and utilization of dietary energy by both impairing fat synthesis and promoting fat-free tissue deposition and resting heat production. Possible mechanisms by which DHEA may affect metabolism are discussed.
3) Dehydroepiandrosterone Acetate COA
|Test Items||Specification||Test Results|
|Description||White to almost white crystalline powder||Conform|
|Loss on drying||≤0.5%||0.20%|
4) Medical Uses
In women with adrenal insufficiency and the healthy elderly there is insufficient evidence to support the use of DHEA.
DHEA is sometimes used as an androgen in hormone replacement therapy (HRT) for menopause. A long-lasting ester prodrug of DHEA, prasterone enanthate, is used in combination with estradiol valerate for this indication.
There is no evidence DHEA is of benefit in treating or preventing cancer. Although DHEA is postulated as an inhibitor towards glucose-6-phosphate dehydrogenase (G6PD) and suppresses leukemia cell proliferation in vitro, DHEA may enhance G6PD mRNA expression, confounding its inhibitory effects.
Evidence is inconclusive in regards to the effect of DHEA on strength in the elderly.
In middle-aged men, no significant effect of DHEA supplementation on lean body mass, strength, or testosterone levels was found in a randomized placebo-controlled trial.
DHEA supplementation has not been found to be useful for memory function in normal middle aged or older adults. It has been studied as a treatment for Alzheimer's disease, but there is no evidence that it is effective.
A review in 2003 found the then-extant evidence sufficient to suggest that low serum levels of DHEA-S may be associated with coronary heart disease in men, but insufficient to determine whether DHEA supplementation would have any cardiovascular benefit.
There is some evidence of short-term benefit in those with systemic lupus erythematosus but little evidence of long-term benefit or safety.
A meta-analysis of intervention studies shows that DHEA supplementation in elderly men can induce a small but significant positive effect on body composition that is strictly dependent on DHEA conversion into its bioactive metabolites such as androgens or estrogens.
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