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|Appearance:||White Crystalline Powder||Whatsapp:||+8613026161792|
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Trilostane Raw Steroid Powders Vetoryl Trilostane 13647-35-3
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|Test Items||Specification||Test Results|
|Appearance||white oralmost white,crystalline powder||Conform|
|Solubility||Freely soluble in water,practically insoluble or very slightly
soluble in alcohol and in methylene chloride.
|Identification||A||The UV absorption spectrum of the sample shows
an absorption maximum at 276nm.The specific
absorbance at the Maximum is55 to 64.
|B||Infraed absorption spectrophotometry.||Conform|
|C||Chromatogram obtained with test solution (b) is
similar in position color & size to the principal spot in the
chromatogram obtained with the reference solution.
|D||An orange-red color develop in methylene chloride layer.||Conform|
|E||It geves reaction (a) of sulphates.||Conform|
|Appearance of solution||Solution S is clear and not more intensely coloured than
reference solution in BY6.
|Optical rotation||negative 0.10° to +0.10°determined on solution S.||+0.01°|
|Acidity or alkalinity||NMT 0.4ml of 0.01M HCL is required to change the color
of the indicator to red.
|Related substances||Impurity J ≤0.20%||Conform|
|Any other impurity ≤0.30%||Conform|
|Total impurity ≤1.0%||Conform|
|Loss on drying||≤0.5%||0.30%|
|Assay(on dried basis)||98.0~101.0%||99.5%|
Trilostane(Vetoryl) Basic Info:
CAS Registry Number: 13647-35-3
Einecs No: 237-133-0
Appearance: : White crystalline powder
Grade: Pharmaceutical Grade
Storage: Shading, confined preservation
1) Trilostane is used in the treatment of Cushing's syndrome. It is normally used in short-term treatment until permanent therapy is possible. Trilostane blocks an enzyme involved in the production of several steroids including cortisol. Inhibiting this enzyme inhibits the production of cortisol. In Cushing's syndrome, the adrenal gland overproduces steroids. Although steroids are important for various functions of the body, too much can cause problems. Trilostane reduces the amount of steroids produced by the adrenal gland.
Trilostane produces suppression of the adrenal cortex by inhibiting enzymatic conversion of steroids by 3-beta-hydroxysteroid dehydrogenase/delta 5,4 ketosteroid isomerase, thus blocking synthesis of adrenal steroids.
2) Trilostane can suppress cortical hormone synthesis process of 3 beta dehydrogenase, make cortisol, aldosterone synthesis reduce, clinical used in the treatment of Cushing syndrome(cortisol increase disease) and primary aldosteronism,the effect is not good than testosterone metyrapone. This product has significantly reduced blood testosterone level role, may relevant to its inhibit synthetic.
Side effect:Symptoms of overdose include darkening of skin, drowsiness or tiredness, loss of appetite, mental depression, skin rash, and/or vomiting.
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