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Mk-677 Ibutamoren SARM Steroid
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MK-677/Ibutamoren mesylate CAS: 159752-10-0
Other name: Ibutamoren mesylate,Nutrobal
Molecular Formula: C28H40N4O8S2
Molecular Weight: 624.77
MOL File: 159752-10-0.mol
Boiling Point: 868.9 °C at 760 mmHg
Flash Point: 479.3 °C
Boiling Point: 868.9 °C at 760 mmHg
Appearance: white powder
Storage: At room temperature
Application: active growth secretagpgie ,mk-677 Effective for age-related fraity Active
Usage: Ibutamoren mesylate (MK-0677) stimulates G H release through a pituitary and hypothalamic receptor that is different from the GH-releasing hormone receptor. MK-677is a drug which acts as a potent, orally active growtn hormone secretagogue, mimicking the GH stimulating action of the endogenous hormone ghrelin. It has been demonstrated to increase the release of, and produces sustained increases in plasma levels of several hormones including growtn hormone, but without affecting cortisol levels. It is currently under development as a potential treatment for reduced levels of these hormones, such as in growtn hormone deficient children or elderly adults, and human studies have shown it to increase both muscle mass and bone mineral density, making it a promising therapy for the treatment of frailty in the elderly. Ibutamoren mesylate (MK-0677) also alters metabolism of body fat and so may have application in the treatment of obesity.
Packing: Exquisite discreet packing : As the customer's requests
Delivery: Express courier.
The min. order is 10 grams.
Functions for MK-0677 :
WHAT IS MK-677:
A secretagogue causes substances to be secreted. MK677 has the ability because of its ability to mimic the GH stimulating action a hormone called "ghrelin." Ghrelin is categorized as a peptide, commonly referred to as "the hunger hormone," which explains the drastic rise in appetite with 677 use. Ghrelin plays a large role in regulating the distribution as well as rate of energy use. It is imperative to understand all of these concepts to decipher the many capabilities that 677 has. mk677 can not only increase plasma levels of many types of hormones, but also provide sustainable increases. These are long term and not just "for the time being" types of increases. Studies show that Nutrobal can increase muscle mass and bone mineral density as well as altering the metabolism of body fat, possibly becoming a treatment for obesity.
BENEFITS OF MK-677:
Increases in fat free mass
Enhanced sleep quality
A treatment for obesity and fat loss
Lowering of bad cholesterol (LDL)
Significant improvements in nitrogen balance
Reversal of diet-induced nitrogen wasting
Treatment of catabolic conditions
Increase in basil metabolic rate
Oral administration (no injections required)
Overall sense of well-being
It is evident by the list of benefits that MK677 is highly desirable. These benefits, in conjunction with the very small chance of side effects show MK677 to be a breakthrough.
As stated above, MK677 carries little to no side effects however it is always important to understand the possibilities that could occur with use.
The main "side effect" associated with MK677 is the increase in appetite, which may be welcome by many research subjects. Studies show this to subside after 4-8 weeks, variant from person to person. The other side effects that showed, that were very infrequent and uncommon were mild lower extremity edema and muscle pain. Secretagogues generally carry the worry of prolactin increase, however studies with MK677 did not show any increase in prolactin levels. Cortisol levels were not increased in studies either. These traits make Nutrobal stand out amongst other chemicals that attempt to work in the same manner but carry these unwanted side effects.
Studies conducted had dosing between 5-25 mg per day, with 25 mg being the most common and effective dose. MK677 has a 24 hour half life and showed to be best tolerated when fed to rats each morning on an empty stomach. MK677 has extreme benefits in regards to helping with a deeper sleep however it can interfere with sleep patterns if taken too late at night or too close to bed time. MK677 can be used continuously for 1-2 years with no concern of desensitizing.
How MK 677 (Nutrobal) Works?
Growthpulse intensity can be increased through 4 possible mechanisms:
Increasing GHRH (growth releasing hormone) release.
Amplifying GHRH signaling in somatotrophs of the anterior pituitary gland.
Reducing somatostatin release (somatostatin turns off GH release).
Inhibiting of somatostatin receptor signaling.
Nutrobal (Mk-677) was found to work through all four of these mechanisms. After ingestion, Growth (GH) was shown to increase dose dependently, at doses starting at 5 milligrams (mgs) a day.
In a study on it's effects on catabolic states, a once daily oral dose of 25mgs was given to healthy young men subjected to short-term diet-induced nitrogen wasting. After 7 days of this dose, the subjects showed a sustained increase in serum concentration of I GF-1 and Hormone; in addition, the nitrogen wasting was reversed, showing great potential for treatment of conditions involving muscle wasting.
Trials testing the effects of this GHS on fighting obesity showed an increase in lean body mass, but neither total, nor visceral adipose tissue was effected. This study gave subjects 25mgs of Nutrobal per day for 8 weeks. The subjects showed an increase in basal metabolic rate after 2 weeks, and an increase in serum levels of GH, I GF-1 and I GF-1 binding protein-3. Increase in lean body mass was hypothesized to be caused by an increase in calorie deposition into the muscle and appetite decrease as opposed to reducing fat storage directly.
A study done for the treatment of osteoporosis and bone mineral density showed some increase in bone density, so there is a true impact on bone mineral density. This can help with injury recovery during your cycle.
Other possible benefits of Nutrobal are associated with improved sleep, improved complexion, increase in energy levels, increase nitrogen retention, increase strength and an improved sense of well being. In addition, some studies also suggest that an increased immune system response was caused by Nutrobal (Mk-677), meaning it boosts the immune system to a degree.
Results have been shown from doses between 5-25mgs a day, dose dependent results should be expected. Higher doses, over 50mgs, have been reported by some, but no need to overdo it.
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