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High Purity Synthetic Steroid Hormone Livial Raw Powder / Tibolone CAS 5630-53-5
1. Tibolone Details:
|Product categories||Biochemistry;Pharmaceuticals;Steroid and hormone|
|Chemical Properties||White solid|
|Usage||A synthetic steroid with weak estrogenic, androgenic and progestogenic activity.A pharamceutical used in the treatment of menopausal syndrome.|
2. Tibolone Features:
Tibolone is a synthetic steroid hormone drug, which is fairly non-selective in its binding profile,
acting as an agonist mainly at estrogen receptors, with a preference for ER alpha. It is used mainly
for treatment of endometriosis,as well as hormone replacement therapy in post-menopausal women. Tibolone has similar or greater efficacy compared to older hormone replacement drugs, but shares
a similar side effect profile.It has also been investigated as a possible treatment for female sexual dysfunction.
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4. Tibolone Application:
In itself Tibolon has no biological activity; the effects are produced mainly by the results of the
activity of its metabolites on various tissues. After administration, it is quickly metabolized into 3α-hydroxytibolon and 3ß-hydroxytibolon compounds, which are also present in an inactive, sulfated
form. A third compound, the Δ4- isomer is formed from Tibolon directly or from the 3ß hydroxymetabolite.
Tibolon has estrogenic effects on bone and vaginal tissue. The Δ4-isomer functions as a progestogen
in endometrial tissue, whereas in the brain and liver it has androgenic effects.In breast tissue, Tibolon acts by strongly inhibiting sulfate activity and weak inhibition of 17α-hydroxysteroid dehydrogenase activity, which results in blocking the conversion of estrone sulfate to E2.
Tibolon Contraindications;Tibolon is contraindicated in patients with the following conditions:Women
with hormone treated tumors,Undiagnosed vaginal bleeding,Pregnancy/lactation,Liver and/or cardiac disease,Tibolon Adverse Drug Effects,Depression,Diarrhea, constipation, nausea, vomiting or
abdominal pain,Visual disturbances,Alteration in results of liver function tests,Excessive fluid retention
in the body tissues resulting in swelling (edema),weight changes, vaginal bleeding, pain in the muscles and joints, rashes or itching,Seborrhoeic dermatitis,Headaches, dizziness, growth of facial hair.
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