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|MF:||C17H19N5||Appearance:||Off-white Color Crystalline Powder|
|MP:||81.0 ~ 84.0℃||CAS:||120511-73-1|
selective estrogen receptor modulators
Anastrozole Arimidex Selective Estrogen Receptor Modulators Steroids MF C17H19N5
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1. Anastrozole Details:
|Product Name||Anastrozole (Arimidex)|
|Melting Point||81.0 ~ 84.0℃|
|Solubility||Freely soluble in methanol,acetone,ethanol and tetrahydrofuran. And very soluble in acetonitrileComplies|
|Standard||Enterprise Standard ,USP|
|Character||An off-white color crystalline powder|
|Usage||It can be used to the treatment of Breast cancer.|
2. Anastrozole Features:
Anastrozole-inhibiting drug approved for treatment of breast cancer after surgery, as well as for metastasis in both pre and postmenopausal women. The severity of breast cancer is increased
by estrogen, as sexhormones cause hyperplasia, and differentiation at estrogen receptor sites.
works by inhibiting the synthesis of estrogen. The trial suggested that is the preferred medical
therapy for Postmenopausal women with localized breast cancer that is estrogen receptor (ER)
positive. Three azole potent selective aromatase inhibitors, which inhibit rely on aromatase
cytochrome P -450 to block estrogen biosynthesis, and the main factors of estrogen to stimulate
breast cancer cell growth. It cantreat breast cancer, especially suitable for those who relapse after treatment with hormone auxiliary advanced breast cancer after menopause women.
3. Anastrozole COA & HPLC:
|Appearance||White crystalline powder|
Conform with standard IR
Conform with standard HPLC
|Total Unspecified Impurity||max. 0.2%||0.08%|
|Individual unspecified impurlty||max. 0.1%||0.05%|
|Related compound B||max. 0.2%||0.07%|
|Related compound C||max. 0.2%||0.04%|
|Related compound D||max. 0.1%||0.05%|
|Related compound E||max. 0.1%||0.06%|
|Limit of cyclohexane||max. 0.08%||ND|
|Limit of ethylacetate||max. 0.1%||0.07%|
|Residue on ignition||max. 0.1%||0.07%|
4. Research of Anastrozole:
Usage in men
Anastrozole has been tested for reducing estrogens, including estradiol, in men. Excess estradiol in
men can cause benign prostatic hyperplasia, gynecomastia, and symptoms of hypogonadism. It can
also contribute to increased risk of stroke, heart attack, chronic inflammation, prostate enlargement
and prostate cancer. Some athletes and body builders use anastrozole as part of their steroid cycle
to reduce and prevent symptoms of excess estrogen--gynecomastia, emotional lability and water retention. Study data suggest dosages of 0.5 mg to 1 mg a day reduce serum estradiol by
approximately 50% in men, which differs in postmenopausal women.
Usage in children
Anastrozole may be used off-label in children with precocious puberty, or children with pubertal gynecomastia. Following the onset of puberty, the epiphyseal plate begins to close due to an increased amount of estrogen production escaping local metabolism and spreading to the circulatory system. It is shown to help slow this process, and increase adult height prediction in adolescent males treated with protein-based peptide hormones for the treatment of growth hormone deficiency.
5. How to Use Anastrozole:
Take this medication by mouth with or without food, usually once a day, or as directed by your doctor.
Use this medication regularly in order to get the most benefit from it. Remember to use it at the same
time each day.
Do not increase your dose or take this medication more often without your doctor's approval. Your condition will not improve any faster and the risk of serious side effects may be increased.
Since this drug can be absorbed through the skin, women who are pregnant or who may become pregnant should not handle or break the tablets of this medication.
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