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|EINECS:||220-097-5||Appearance:||White Or Off-white Solid|
pharmaceutical grade powder
99% Purity Pharmaceutical SARM Powder Aicar CAS 2627-69-2 for Weight Loss
1) Aicar Details:
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Product Categories: Carbohydrates & Derivatives;Nucleotides;Protein Kinase;Cardiovascular
Chemical Properties:white or off-white solid
Usage:glucose uptake stimulant; AMPK activator.AICAR is a nucleoside analogue that is able to enter nucleoside pools and is able to significantly increase levels of adenosine during periods of ATP breakdown. Adenosine-regulating agents (ARAs) hav e been recognized for therapeutic potential in myocardial ischemia. Cardioprotective.
Packing:foil bag or as required
2) Aicar Function:
AICAR (chemical name: 5-Aminoimidazole-4-carboxamide ribonucleotide) is a peptide, which is an intermediate within the generation of inosine monophosphate and directly related to metabolic regulation. The most important mechanism that AICAR is known for is its ability to block enzymes both in intracellular and extracellular levels, which, in turn, allows for an accelerated stimulation of glucose uptake and increase protein kinases in skeletal muscle tissue. These two functions allow for more energy conversion, which helps burn fat and also sustain output in activity. This is what scientists and athletes/bodybuilders are interested in, but there are some amazing side effects.
Interestingly, AICAR has been shown to protect against ischemic injury. This type of injury is directly related to the restriction of blood to tissues, which can cause insufficient amounts of oxygen and glucose needed to keep the tissue alive. This can lead to thrombosis, embolisms, and vasoconstriction. AICAR can be used as a stabilizing peptide for ischemic episodes, and it can allow for proper blood flow to the myocardium (heart). This function is very interesting, as AICAR could be fundamentally used to treat the heart muscle in the aftermath of a heart attack. This might reduce the possibility for ischemic injuries. Abnormal growths of heart tissues and heart valve function have also been altered in animal studies that used the peptide AICAR, which is a downside.
3) Aicar Dosage and Usage:
Here is where AICAR becomes a pipe dream for anyone who is not a top level endurance athlete or bodybuilder. The dosages recommended to achieve the benefits from this peptide are insanely high. AICAR must be dosed at around 500mgs per kilogram (kg) of body weight. A gram of real pure AICAR can cost $100 USD or more, so single dosages for humans could be well in to the several hundreds of dollars! Some say that this can be circumvented by stacking it with Cardarine (GW), but you still need to spend a lot of money for perhaps little to no result if you are not dosing high enough dosages.Yes, the peptide AICAR has amazing properties, some which even show the slowing of growth in cancer cells, but for the average athlete this has no basis in a day to day regiment. On the other hand, Cardarine (GW) has been shown to provide users with more than enough results as an Activated Receptor d agonists (PPARd) and it's cost-effective for everyone.
4) Aicar COA:
|Related substance (HPLC)||Total impurity ≤0.5%
Max single impurity ≤0.1%
|Sieve analysis||100% pass 80 mesh||Complies|
|Loss on Drying
Residue on Ignition
|Total Plate Count||<1000cfu/g||Complies|
|Yeast & Mold||<100cfu/g||Complies|
5) Medical Use
A brief period of coronary arterial occlusion followed by reperfusion prior to prolonged ischemia is known as preconditioning. It has been shown that this is protective. Preconditioning preceded myocardial infarction, may delay cell death and allow for greater salvage of myocardium through reperfusion therapy. AICAR has been shown to precondition the heart shortly before or during ischemia. AICAR triggers a preconditioned anti-inflammatory state by increasing NO production from endothelial nitric oxide synthase. When AICAR is given 24 hours prior to reperfusion, it prevents post ischemic leukocyte-endothelial cell adhesive interactions with increased NO production. AICAR-dependent preconditioning is also mediated by an ATP-sensitive potassium channel and hemeoxygenase-dependent mechanism. It increases AMPK-dependent recruitment of ATP-sensitive K channels to the sarcolemma causing the action potential duration to shorten, and preventing calcium overload during reperfusion. The decrease in calcium overload prevents inflammation activation by ROS. AICAR also increases AMPK-dependent glucose uptake through translocation of GLUT-4 which is beneficial for the heart during post-ischemic reperfusion. The increase in glucose during AICAR preconditioning lengthens the period for preconditioning up to 2 hours in rabbits and 40 minutes in humans undergoing coronary ligation. As a result, AICAR reduces the frequency and size of myocardial infarcts up to 25% in humans allowing improved blood flow to the heart. As well, the treatment has been shown to decrease the risk of an early death and improve recovery after surgery from an ischemic injury.
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